Symptoms of High Acetylcholine

Posted on October 26th, 2011 by admin

Subdued or depressed mood
Anhedonia (inability to experience pleasure)
Difficulty concentrating
Difficulty with higher-order or complex thought processes
Mental fatigue
Mental confusion
Memory problems
Decreased motivation
Feeling overly sleepy or tired (particularly in the evening), despite adequate sleep and rest
Difficulty understanding or performing tasks
Pessimistic, negative ideation or rumination
Feelings of helplessnes and hopelessness
Irritability or anger
Emotional heightening and lability
Blurred vision
Dry mouth
Altered sense of smell; heighted sensitivity to odors; olfactory delusions
Stomach pain or discomfort
Intestinal gas or bloating
Diarrhea or constipation
Nausea, dizziness, and vomiting
Muscle pain or discomfort
Joint pain, discomfort, or swelling
Tooth or jaw pain or discomfort
Tingling or numbness in arms or legs
Muscle weakness
Increased urinary frequency or problems with bladder control
Flu or cold-like symptoms
Weakening of immune system and increased susceptibility to illness
Nasal discharge
Chills or sensation of cold
Cold feet, hands
Sleep disturbance
More and vivid dreaming, and higher incidence of nightmares
Decreased levels in the brain of the neurotransmitters, serotonin, norepinephrine,  and dopamine
Interference with the release of the above brain transmitters, because of higher inhibition

There is an inverse, antagonistic relationship between acetycholine (ACh) and serotonin (SE) in the brain. In other words as the quantity of one increases, the quantity of the other decreases. A certain amount of ACh is necessary for normal, optimal brain function. Memory, motivation, higher-order thought processes, sexual desire and activity, and sleep (among other things) depend on ACh. In lower amounts, ACh can act like a stimulant by releasing norepinephrine (NE) and dopamine (DA).  However, those brain chemicals are used up (depleted) in the process; and a deficiency can occur. Too much ACh relative to other brain chemicals such as SE, NE, and DA has an adverse effect on brain function. This is because in larger quantities ACh acts like an inhibitory neurotransmitter, causing increased nervous system inhibition (depression). Important to remember is that, in general, as ACh levels go up in the brain, the levels of the other brain transmitters go down.

In terms of mood, the combination of higher ACh and NE, together with lower SE, produces anxiety, emotional lability, irritability, anger, aggressiveness, negative rumination, impatience, and impulsiveness (among other things). When NE, DA, and SE are low and acetylcholine is high, the result is simply depression. SSRI antidepressants, by increasing serotonin, are able to lower acetylcholine levels, thereby lessening or eliminating the symptoms associated with high acetylcholine. However, the major drawback is that increasing serotonin also leads to a reduction of norepinephrine and dopamine in the brain. Therefore, long-term use of SSRI antidepressants will result in a high serotonin condition, which is actually another type of depression (see separate article on this site about serotonin). So, in spite of all of the publicity and common usage, SSRI antidepressants are really not the best choice (at least, not in the long run) for treating depression. Unless the problem of low NE and DA is also addressed, a high acetylcholine depression, in time, will merely be replaced by a high serotonin depression. This explains why SSRI antidepressants do not help everyone, lose their effectiveness over time, make some people more depressed, or cause intolerable side effects.

Generally, ACh levels in the brain will increase proportionately to the amount of choline in the diet. However, ACh levels will also become higher for other reasons. Whenever there is interference with the release of the other neurotransmitters, or their levels have fallen, ACh levels will automatically increase. This is due to the balancing effect between all of the brain transmitters, whereby a decrease in one resuts in a relative increase in the other.

Foods that significantly increase ACh: eggs, fish, soybean products, foods (wide variety) containing lecithin, wheat germ.

Supplements that significantly increase ACh: choline, lecithin, fish oil, flaxseed oil, vitamin B5 (pantothenic acid).

Other things that increase acetylcholine: MSG (monosodium glutamate), medications, chemicals, physical activity (exercise, work).

Note that some people are more sensitive to choline and, therefore, will experience greater problems than usual with the consumption of the above foods and supplements.  Also, reaction to choline may be age-dependent, with older people generally experiencing more sensitivity.

For more information see:

Posted in Articles | 4 Comments

4 Responses to “Symptoms of High Acetylcholine”

  1. mwe says:

    Dear admin,

    very interesting article. Thank you for this.

    BUT: How can this kind of depression be healed?

    Conclusion?! Taking supplements that:
    – increase serotonin, dopamine and norepinephrine
    – help LOWERING acetylcholine levels and/or
    – INHIBIT cholin-acetyltransferase ChAT and/or
    – ACTIVATE Acetylcholinesterase AChE and/or
    – DESENSITIZE cholinergic system receptors

    I don’t know, if this conclusion is correct.

    Could you provide help?

    Thanks in advance


  2. sean says:

    Hey I was curious how you compiled this list of symptoms. If you had any sources you could link to that would be greatly appreciated. I am dealing with most of these symptoms currently and wondered if you had any recommendation for lowering Ach. Thanks!

    • admin says:

      The symptoms in the list are those that I have repeatedly experienced over many years duration or have observed in other people, with some concurrence from reliable information sources. Determining the symptoms, in part, involves knowing what supplements, food, etc., contain considerable amounts of choline or other precursors to acetylcholine, eating or using them, and noting what occurs afterward. This is done many times to verify the results.

      Lowering acetylcholine basically requires being aware of what it is that you are taking, eating, or doing that causes the levels to rise and then stopping those things (at least temporarily), after which acetylcholine levels will start gradually to decrease. Also, you can eat food or take supplements, drugs, etc. that increase serotonin, which lowers acetylcholine or counteracts the symptoms of high acetylcholine.

      The complete answer to your questions is more complex; but, hopefully, the above will be of some help.

      Except for the links provided, at this time, I am not aware of any other good sources of information–although there may be.

  3. sean says:

    Thanks for getting back to me. Yeah, I have had quite an unusual reaction to a choline supplement I took, CDP Choline and it seems to have residual effects that have lasted about 5 months now. Your list is the most comprehensive one I have found for high acetylcholine and I have experienced or continue to experience nearly all of the symptoms listed on it. Here is a thread I posted about my experience: Have you ever heard of any other long-lasting reaction like this before?

    Thanks again for your help and your website.

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